马昆 高级研究员

深圳市华大基因研究院，高级研究员，高级科学顾问。运用“两侧对称动物胚胎左右分隔原理”，初步建立了一个高效的、发现导致人类复杂疾病发生的技术平台。独立研究两侧对称动物胚胎左右分隔原理。MRC Human Genetics Unit, 英国爱丁堡 1990.04-1995.04攻读博士学位，分子生物专业。导师: Dr. Ann Chandley, Professor Howard Cooke. Thesis: AY chromosome gene family with RNA-binding protein homology: candidate for the azoospermia factor AZF controlling human spermatogenesis.

中国科学院昆明动物研究所 1982年9月-1986年1月硕士学位，细胞生物专业.导师: 施立明教授

Thesis: Comparative studies on spermatocytes of Chinese muntjac Muntiacus reevesi, Black muntjac M. crinifrons and Indian muntjac M. muntjac

19 78 年9月-19 82 年7月在云南大学生物系动物学专业攻读学士位。

2014.08-至今在华大基因研究院（BGI Research Institute） 任高级研究员，高级科学顾问。

发表论文（部分）

 1. Geng Liu, Dongli Li, Si Qiu1, Wenhui Li1, Cheng-chi Chao, Naibo Yang, Handong Li, Zhen Cheng, Xin Song, Le Cheng, Xiuqing Zhang, Jian Wang1, Huanming Yang1, Kun Ma, Yong Hou, Bo Li (2017): PSSMHCpan: a novel PSSM based software for predicting class I peptide-HLA binding affinity (co-corresponding author) Gigascience in press

2. Si Qiu, Wenhui Li, Yali Bai, Kui Wu, Xiuqing Zhang, Huanming Yang, Kun Ma, Yong Hou, Bo Li (2016): Single-cell RNA sequencing reveals dynamic changes in A-to-I RNA editome during early human embryogenesis. BMC Genomics 17:766 DOI 10.1186/s12864-016-3115-2 (co-corresponding author)

3. Ma K. (2013): Embryonic Left-Right Separation Mechanism Allows Confinement of Mutation-induced Phenotypes to One Lateral Body Half of Bilaterians. American J Medical Genetics Part A 161 (12):3095-3114. DOI: 10.1002/ajmg.a.36188. (corresponding author)

4. Salehian B., Taylor W., Ma K. (2006): The Effect of Glutamine on Prevention of Glucocorticoid Induced Skeletal Muscle Atrophy is Associated with Myostatin Suppression. Metabolism, Sep; 55(9):1239-47

5. Ma K., Mallidis C., Mahabadi,V., Artaza J., Gonzalez-Cadavid N. Bhasin S., Salehian B. (2003): Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin expression. American J. Physiology (Endocrinology), 285 :E363-E371 (corresponding author)

6. Artaza J. N., Bhasin S., Mallidis C., Taylor W., Ma K., Gonzalaz-Cadavid N. F. (2001): Endogenous expression and localization of myostatin and its relation to MHC distribution in C2C12 skeletal muscle. Journal of Cellular Physiology, 190: 170-179

7. Ma K., Mallidis C., Taylor, W., Gonzalez-Cadavid N. Bhasin S (2001): Characterization of the 5’ Upstream Regulatory Region of the Human Myostatin Gene: Regulation of Myostatin Gene Transcription by Dexamethasone in vitro. American J. Physiology (Endocrinology), 281 (6):E 1128-36(corresponding author)

8. Bhasin S., Mallidis C., Ma K. (2000): The genetic basis of infertility in men. Baillieres Best Pract Res Clin Endocrinol Metab. 14(3):363-388

9. Cram D.S.*, Ma K.*, Bhasin S., Arias J., Pandjaitan M., Chu B., Auidrins P., Saunders D., Quinn F., de Kretser D.M., McLachlan R. (2000): Y chromosome analysis of infertile men and their ICSI-conceived sons: Vertical transmission of deletions and rarity of de novo deletions. Fertil Steril. 74(5):909-915. (*Equal contribution)

10. K. Ma, C. Mallidis, S.Bhasin (2000): The role of Y chromosome microdeletions in male infertility. Eur. J. Endo. 142: 418-430 (corresponding author)